Individuals with MS often experience unpredictable changes in disease-related symptoms such as fatigue, muscle weakness, poor balance and co-ordination. Previous research in females with MS has suggested that these symptoms have the potential to be worsened at key points of the menstrual cycle.
Specifically, just before or during menstruation, these variables are negatively impacted.
Despite this preliminary evidence, no study has yet provided a detailed overview of individual symptom changes, and their severity, across the menstrual cycle. Furthermore, there have been no mechanistic studies that investigate changes within the nervous system to explain these findings, meaning that females with MS and the clinicians that support them cannot predict or manage symptoms appropriately.